Daptomycin 103060-53-3 mo nga mate hopuhopu
Taipitopito Hua
| Ingoa | Daptomycin |
| nama CAS | 103060-53-3 |
| tātai rāpoi ngota | C72H101N17O26 |
| Te taumaha ngota | 1620.67 |
| Tau EINECS | 600-389-2 |
| Te rewa | 202-204°C |
| Kohuatanga | 2078.2±65.0 °C (Te Matapae) |
| Kiato | 1.45±0.1 g/cm3(Te Matapae) |
| Kohikohiko | 87℃ |
| Nga tikanga rokiroki | Kua hiritia ki te maroke, Whakaorangia ki roto i te pouaka tio, i raro i te -20°C |
| Wairewa | Mewaro: whakarewa5mg/mL |
| Te whakarea kawa | (pKa) 4.00±0.10 (Te Matapae) |
| Puka | paura |
| Tae | kore tae ki te kowhai ngoikore |
Nga kupu taurite
N-[N-(1-Oxodecyl)-L-Trp-D-Asn-L-Asp-]-cyclo[L-Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp-Gly-D-Ser-[(3R)-3-methyl-L-Glu-]-4-)L-4-Aminophenyl ;N-[N-Decanoyl-L-Trp-D-Asn-L-Asp-]-cyclo[Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp-Gly-D-Ser-[(3R)-3-methyl-L-Glu-]-3-(2-Labenzoyl)-]-O ecyl)-L-tryptophyl-D-asparaginyl-L-α-aspartyl-L-threonylglycyl-L-ornithinyl-L-α-aspartyl-D-alanyl-L-α-aspartylglycyl-D-seryl-(3R) -3-methyl-L-α- glutamyl-α,2-diamino-γ-oxo-benzenebutanoicacid(13-4)lactone;DAPTOMYCINE;Dapcin;Daptomycin,>=99%;DaptomycinReadyMadeSolution;Daptomycin(LY146032)
Whakaahuatanga
Ko te daptomycin paturopi he antibiotic lipopeptide cyclic me te hanganga hou i tangohia mai i te hupa fermentation o Streptomyces (S. reseosporus), e aukati ana i te biosynthesis o te peptidoglycan pakitara huakita ma te whakararuraru i te kawe o nga waikawa amino i roto i te membrane pūtau. Ko te whakarereke i nga ahuatanga o te kiriuhi cytoplasmic ka taea te whakararu i te mahi membrane kitakita i roto i nga huarahi maha me te patu tere i nga huakita Gram-positive. I tua atu i tona kaha ki te mahi i runga i te nuinga o nga huakita Gram-positive e pa ana ki te haumanu, he mea nui ake te daptomycin mo nga riaka taratahi kua whakaatu te atete ki te methicillin, vancomycin, me te linezolid in vitro. He kaha te mahi, a he mea tino nui nga paanga haumanu o tenei taonga mo nga turoro mate kino. Ko te Eosinophilic pneumonia he mate onge, tino kino me nga tohu penei i te kirika, te maremare, te poto o te manawa, me te uaua ki te manawa.
Pānga Patukino
He pai te mahi bacteriostatic a Daptomycin ki nga momo huakita aukati paturopi, penei i te MIC=0.06-0.5 μg/ml mo te Staphylococcus aureus (MRSA), me te Staphylococcus aureus (MRSA) ātete ki te methicillin. MIC=0.0625～1μg/ml mō te huakita, MIC=0.12～0.5μg/ml mō te Staphylococcus epidermidis ātete oxacillin, MIC=2.5μg/ml mō te enterococcus tino ātete ki te aminoglycoside paturopi, MIC=2.5μg/ml mo te Gmr MICrBIa o te Enterococcus 0.5～1μg/ml, me te MIC o Enterococcus ātete ki te glycopeptide antibiotic ko 1～2μg/ml.
