Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH

Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH

Taupānga Rangahau:
Ko tenei pūhui he parenga, he lysine derivative kua whakamahia i roto i te whakahiato peptide me te whanaketanga conjugate tarukino. Kei roto i te roopu Fmoc mo te whakamarumaru N-terminal, me te whakarereke-taha me te Eic(OtBu) (waikawa heicosanoic derivative), waikawa γ-glutamic (γ-Glu), me te AEEA (aminoethoxyethoxyacetate). I hangaia enei waahanga ki te ako i nga paanga lipidation, te matū mokowhiti, me te tuku raau taero. Kei te rangahau whanui i roto i te horopaki o nga rautaki prodrug, hononga ADC, me nga peptides tauwhitiwhiti membrane.

Taumahi:
Ko te Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH hei poraka whare mo te whakahiato i nga peptides kua whakarerekehia te lipid, i nga punaha tuku tarukino ranei. Ko te Eic moiety te whakapai ake i te lipophilicity me te here membrane; γ-Glu tāpiri pūmautanga enzymatic me te whai i te kaha; me te AEEA hei hononga honohono hydrophilic ngawari. Ka hono tahi, ka taea e raatau te hanga peptides me te kaha ake o te tango i nga pūtau, te haurua o te ora, me nga taonga tuku-a-papa.