Liraglutide Anti-Diabetics mo te Mana Huka Toto CAS NO.204656-20-2
Taipitopito Hua
| CAS | 204656-20-2 | Tātai rāpoi | C172H265N43O51 |
| Taumaha rāpoi | 3751.20 | Te ahua | Mā |
| Tikanga Rokiroki | Te parenga marama, 2-8 tohu | Mōkī | Peeke pepa konumohe / ipu |
| Maamaa | ≥98% | Te kawe waka | Te mekameka makariri me te tuku rokiroki pai |
Nga waahanga o te Liraglutide
Ingredient Active:
Ko te Liraglutide (he rite ki te glucagon-like peptide-1 (GLP-1) te tangata i hangaia e te rewena na roto i te hangarau whakakotahitanga ira).
Ingoa matū:
Arg34Lys26-(N-ε-(γ-Glu(N-α-hexadecanoyl)))-GLP-1[7-37]
Ētahi atu Kai:
Disodium Hydrogen Phosphate Dihydrate, Propylene Glycol, Hydrochloric Acid and/ranei Sodium Hydroxide (hei Whakariterite pH Anake), Phenol, me te Wai mo te Werohanga.
Taupānga
Te mate huka momo 2
Ko te Liraglutide te whakapai ake i te whakahaere o te huka toto. Ka whakahekehia te hyperglycemia e pa ana ki te kai (mo te 24 haora i muri i te whakahaerenga) ma te whakanui ake i te hunanga o te insulin (anake) ina hiahiatia ma te whakanui ake i nga taumata huka, te whakaroa i te tukunga o te kopu, me te peehi i te hunanga o te glucagon prandial.
He pai mo nga turoro kei te ngoikore tonu te whakahaere o te huka toto i muri i te horopeta teitei o te metformin me te sulfonylurea anake. Ka whakamahia tahi me te metformin me te sulfonylureas ranei.
Ka mahi i runga i te tikanga e whakawhirinaki ana ki te hukahuka, te tikanga ka whakaihiihi i te hunanga o te insulin mena ka piki ake nga taumata o te huka toto i te tikanga, kia kore ai e "tuwhera". Na tenei, he iti noa te tupono o te hypoglycemia.
Kei a ia te kaha mo te aukati i te apoptosis me te whakaongaonga i te whakaoranga o nga pūtau beta (ka kitea i roto i nga rangahau kararehe).
Ka whakahekehia te hiahia me te aukati i te piki o te taumaha o te tinana, penei i te rangahau mahunga ki te upoko ki te glimepiride.
Mahi Rongoa
Ko te Liraglutide he tairitenga GLP-1 me te 97% te raupapa homology ki te GLP-1 tangata, ka taea te here me te whakahohe i te kaikawe GLP-1. Ko te kaiawhina GLP-1 te whainga o te GLP-1 taketake, he taiaki incretin endogenous e whakatairanga ana i te hunanga o te insulin e whakawhirinaki ana ki te kukū mai i nga pūtau β pancreatic. Kaore i rite ki te GLP-1 taketake, ko nga korero mo te rongoa me te rongoa rongoa o te liraglutide i roto i te tangata e pai ana mo te tikanga whakangao mo ia ra. I muri i te werohanga i raro i te kiri, ko tana tikanga mo te mahi roa ko: te hononga-whaiaro e whakaroa ana i te whakauru; herea ki albumin; He teitei ake te pumau o te whaariki, ka roa ake te haurua o te plasma.
Ko te mahi o te liraglutide ka takawaenga e tana taunekeneke motuhake me te kaiawhina GLP-1, na te pikinga o te cyclic adenosine monophosphate (cAMP). Ko te Liraglutide e whakaihiihi ana i te hunanga o te insulin i runga i nga tikanga e whakawhirinaki ana ki te kukū o te huka, me te whakaheke i te nui o te glucagon i runga i te tikanga e whakawhirinaki ana ki te hukahuka.
No reira, ka piki ake te huka toto, ka whakaihiihihia te hunanga o te insulin, i te mea ka aukatihia te hunanga o te glucagon. Engari, ka whakahekehia e te liraglutide te hunanga o te insulin i te wa o te hypoglycemia me te kore e pa ki te hunanga glucagon. Ko te tikanga hypoglycemic o te liraglutide kei roto ano hoki te roanga o te wa putunga o te kopu. Ka whakaitihia e te Liraglutide te taumaha tinana me te papatipu ngako tinana ma te whakaiti i te hiakai me te kaha o te kai.
