I nga tau tata nei, ko te maimoatanga o te momona me te momo mate huka momo 2 kua puta te ahunga whakamua. Whai muri i nga agonists whakawhiwhi GLP-1 (hei tauira, Semaglutide) me nga agonists rua (hei tauira, Tirzepatide),Retatrutide(LY3437943), atoru agonist(GLP-1, GIP, me te glucagon receptors), kua whakaatu i te kaha o mua. Na nga hua whakamiharo i roto i te whakaheke taumaha me te whakapai ake i te metabolic, e kiia ana he rongoa pakaru mo nga mate metabolic.
Hangahanga Mahi
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GLP-1 whakahohenga receptor: Whakarei ake i te hunanga o te insulin, ka pehi i te hiahia, ka whakaroa te putunga o te kopu.
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Whakahohenga kaiwhakawhiwhi GIP: Ka whakanui i nga hua whakaheke huka o te GLP-1, ka pai ake te tairongo o te insulin.
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Whakahohenga kaiwhakawhiwhi Glucagon: Ka whakatairanga i te whakapaunga o te kaha me te ngako.
Ko te whakakotahitanga o enei kaiwhakawhiwhi e toru ka taea e Retatrutide te nui atu i nga raau taero i roto i te whakaheke taumaha me te whakahaere glycemic.
Raraunga Whakamātau Haumanu (Wahanga II)
I roto i te aWhakamatautanga o te wahanga II me te 338 nga turoro taumaha/momomo, I whakaatu a Retatrutide i nga hua tino pai.
Ripanga: Whakatauritenga o Retatrutide ki Placebo
| Te horopeta (mg/wiki) | Te Whakaheke Taumaha (%) | HbA1c Whakaheke (%) | Nga Mahi kino noa |
|---|---|---|---|
| 1 mg | -7.2% | -0.9% | Nausea, ngawari te ruaki |
| 4 mg | -12.9% | -1.5% | Nausea, mate hiahia |
| 8 mg | -17.3% | -2.0% | Te mamae o te GI, te mate pukupuku ngawari |
| 12 mg | -24.2% | -2.2% | Nausea, mate hiahia, constipation |
| Placebo | -2.1% | -0.2% | Kaore he huringa nui |
Tirohanga Raraunga (Whakataurite Whakaiti Taumaha)
Ko te tūtohi pae e whai ake nei e whakaatu ana i tewhakaiti taimaha tohariteputa noa i nga horopeta Retatrutide rereke i whakaritea ki te placebo:
Te wa tuku: Sep-16-2025