Kupu Whakataki
Ko Tirzepatide, i whakawhanakehia e Eli Lilly, he rongoa peptide hou e tohu ana i tetahi tohu nui mo te maimoatanga o te mate huka momo 2 me te momona. Kaore i rite ki nga agonists tuku iho GLP-1 (glucagon-like peptide-1), ka mahi a Tirzepatide.GIP e rua (te insulinotropic polypeptide e whakawhirinaki ana ki te huka)aNga kaiwhakawhiwhi GLP-1, ka whiwhi i te tohu aagonist kaiwhakawhiwhi rua. Ma tenei mahi takirua ka taea te kaha ki te whakahaere i te huka toto me te whakaheke i te taumaha o te tinana, ina koa mo nga turoro me te mate huka momo 2 me te momona.
Hangahanga Mahi
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Whakahohenga kaiwhakawhiwhi GIP: Whakarei ake te hunanga o te insulin me te whakapai ake i te manawanui o te huka.
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GLP-1 whakahohenga receptor: Ka whakatairanga i te tukunga o te insulin, ka pehia te hunanga o te glucagon, me te whakaroa i te putunga o te kopu.
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Te mahi takirua: Ka whakarato i te mana glycemic whai hua me te whakaheke taumaha.
Tātari Raraunga Haumanu
1. WHAKAMAHI KI TE WHAKAMAHI (Maka Mate Momo 2)
Puta noa i te mahaSURPASS nga whakamatautau haumanu, Tirzepatide i runga ake i te insulin me te Semaglutide i roto i nga hua glycemic me te whakaheke taimaha.
| Rōpū Turoro | Te horopeta | Tauwaenga HbA1c Whakaiti | Tauwaenga Ngaronga Taumaha |
|---|---|---|---|
| Momo mate huka 2 | 5 mg | -2.0% | -7.0 kg |
| Momo mate huka 2 | 10 mg | -2.2% | -9.5 kg |
| Momo mate huka 2 | 15 mg | -2.4% | -11.0 kg |
➡ Ka whakatauritea ki a Semaglutide (1 mg: HbA1c -1.9%, Taumaha -6.0 kg), i whakaatu a Tirzepatide i nga hua pai ake i roto i te whakahaere glycemic me te mate taimaha.
2. Whakamatautau SURMOUNT (Momona)
I roto i nga turoro momomo kaore he mate huka, i whakaatu a Tirzepatide i te kaha o te whakaheke taumaha.
| Te horopeta | Tauwaenga Whakaheke Taumaha (72 wiki) |
|---|---|
| 5 mg | -15% |
| 10 mg | -20% |
| 15 mg | -22.5% |
➡ Mo te manawanui 100 kg te taumaha, ka taea e te Tirzepatide horopeta teitei te whakaiti i te taumaha huri noa.22.5 kg.
Nga Painga Matua
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Tikanga takirua: I tua atu i nga agonists GLP-1 kotahi.
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Te kaha pai: He whai hua ki te whakahaere glycemic me te whakahaere taumaha.
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Te whakamahi whanui: He pai mo te mate huka me te momona.
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Te kaha o te maakete: Te piki haere o te tono mo nga tuunga maimoatanga momoma Tirzepatide hei rongoa mo te heke mai.
Tirohanga maakete
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Matapae rahi o te maakete: Hei te tau 2030, ko te maakete tarukino GLP-1 o te ao ka nui akeUSD 150 piriona, me Tirzepatide pea ka hopu i tetahi hea rangatira.
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Whenua whakataetae: Ko te whakataetae matua ko Novo Nordisk's Semaglutide (Ozempic, Wegovy).
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Painga: Ko nga raraunga haumanu e whakaatu ana ko Tirzepatide e whakarato ana i te mate taimaha nui atu i te Semaglutide, e whakapakari ana i tana whakataetae maakete i roto i te maimoatanga mo te mate.
Te wa tuku: Sep-12-2025