Nga Kai Rongoa
-
Fmoc-Lys(Pal-Glu-OtBu)-OH
Ko te Fmoc-Lys(Pal-Glu-OtBu)-OH he poraka hangahanga waikawa amino lipidated motuhake i hangaia mo te whakakotahitanga peptide-lipid. Kei roto i te lysine e tiakina ana e Fmoc me te mekameka taha palmitoyl-glutamate, te whakarei ake i te hononga membrane me te koiora.
-
Fmoc-His-Aib-OH
Ko te Fmoc-His-Aib-OH he poraka hangahanga dipeptide e whakamahia ana i roto i te whakahiato peptide, te whakakotahi i te histidine kua tiakina e Fmoc me te Aib (a-aminoisobutyric acid). Ka whakaatu a Aib i te rigidity conformational, he mea nui mo te hoahoa peptides helical me te pumau.
-
Boc-Tana(Trt)-Aib-Glu(OtBu)-Gly-OH
Ko te Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH he kongakonga tetrapeptide kua tiakina e whakamahia ana i roto i te whakahiato peptide me te whanaketanga tarukino. Kei roto i nga roopu mahi kua parea rautaki mo te hono takahanga me te whakaatu i te Aib (a-aminoisobutyric acid) hei whakarei ake i te pumau o te helix me te rigidity conformational.
-
Ste-γ-Glu-AEEA-AEEA-OSU
Ko te Ste-γ-Glu-AEEA-AEEA-OSU he ngota ngota whakahiato lipid kua hangaia mo te tuku raau taero me te whakakotahi i nga raau taero antibody (ADC). Kei roto i te stearoyl (Ste) hydrophobic hiku, he γ-glutamyl motif arotahi, AEEA mokowhiti mo te ngawari, me te roopu OSu (NHS ester) mo te whakakotahi pai.
-
Fmoc-Ile-αMeLeu-Leu-OH
Ko te Fmoc-Ile-αMeLeu-Leu-OH he paraka hanga tripeptide kua parea ki te waihanga e whakaatu ana i te α-methylated leucine, e whakamahia nuitia ana i roto i te hoahoa tarukino peptide hei whakarei ake i te pumau o te tinana me te kowhiringa o te kaikawe.
-
Dodecyl Phosphocholine (DPC)
Ko te Dodecyl Phosphocholine (DPC) he waipara zwitterionic waihanga e whakamahia nuitia ana i roto i te rangahau pūmua membrane me te koiora hanganga, ina koa i roto i te NMR spectroscopy me te crystallography.
-
Donidalorsen
Ko te Donidalorsen API he antisense oligonucleotide (ASO) kei te tirotirohia mo te maimoatanga o te angioedema tuku iho (HAE) me nga ahuatanga mumura e pa ana. Kei te akohia i roto i te horopaki o nga maimoatanga e arotahi ana ki te RNA, e whai ana ki te whakaiti i te whakapuaki oplasma prekallikrein(KLKB1 mRNA). Ka whakamahia e nga Kairangahau a Donidalorsen ki te tuhura i nga tikanga whakangau ira, te rongoa rongoa-a-ipurangi, me te whakahaere mo te wa roa mo te mumura-a-bradykinin.
-
Fitusiran
Ko te API Fitusiran he RNA pokanoa iti (siRNA) i tirotirohia i roto i te waahi o te mate hemophilia me te mate coagulation. E whai ana i teantithrombin (AT, SERPINC1 ranei)ira i roto i te ate hei whakaiti i te hanga antithrombin. Ka whakamahia e nga Kairangahau a Fitusiran ki te tirotiro i nga tikanga wawaotanga RNA (RNAi), te whakangau ira ira motuhake mo te ate, me nga rautaki rongoa hou mo te whakahoki ano i te coagulation i roto i nga turoro hemophilia A me B, me te kore aukati ranei.
-
Givosiran
Ko te Givosiran API he RNA whakaporearea iti (siRNA) i akohia mo te maimoatanga o te porphyria ate whakapeka (AHP). Ka aro nui ki teALAS1ira (aminolevulinic acid synthase 1), e uru ana ki te ara koiora heme. Ka whakamahia e nga Kairangahau a Givosiran ki te tirotiro i nga whakamaaramatanga a te RNA interference (RNAi), te whakangao ira ira, me te whakarereketanga o nga huarahi metabolic e uru ana ki te porphyria me nga mate ira e pa ana.
-
Plozasiran
Ko te Plozasiran API he RNA pokanoa iti (siRNA) i hangaia mo te maimoatanga o te hypertriglyceridemia me nga mate o te ngakau me te metabolic. E whai ana i teAPOC3ira, e whakawaehere ana i te apolipoprotein C-III, he kaiwhakahaere matua o te paopaotanga triglyceride. I roto i te rangahau, ka whakamahia a Plozasiran ki te ako i nga rautaki whakaheke lipid-a-RNAi, te motuhake-whakamutunga ira, me nga maimoatanga roa mo nga ahuatanga penei i te whanau chylomicronemia syndrome (FCS) me te dyslipidemia whakauru.
-
Zilebesiran
Ko te Zilebesiran API he RNA pokanoa iti (siRNA) i whakawhanakehia mo te maimoatanga o te whakaheke toto. E whai ana i teAGTira, e whakawaehere ana i te angiotensinogen—he waahanga matua o te punaha renin-angiotensin-aldosterone (RAAS). I roto i te rangahau, ka whakamahia a Zilebesiran ki te ako i nga huarahi whakangao ira mo te whakahaere i te pehanga toto mo te wa roa, nga hangarau tuku RNAi, me te mahi whanui o te ara RAAS i roto i nga mate ngakau me nga whatukuhu.
-
Ko te Caspofungin mo nga Infections Antifungal
Ingoa: Caspofungin
Nama CAS: 162808-62-0
tātai rāpoi: C52H88N10O15
Te taumaha ngota: 1093.31
Nama EINECS: 1806241-263-5
Ira kohua: 1408.1±65.0 °C (Te Matapae)
Kiato: 1.36±0.1 g/cm3(Whakaahua)
Te whakarea kawatanga: (pKa) 9.86±0.26 (Te Matapae)