Hua
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Givosiran
Ko te Givosiran API he RNA whakaporearea iti (siRNA) i akohia mo te maimoatanga o te porphyria ate whakapeka (AHP). Ka aro nui ki teALAS1ira (aminolevulinic acid synthase 1), e uru ana ki te ara koiora heme. Ka whakamahia e nga Kairangahau a Givosiran ki te tirotiro i nga whakamaaramatanga a te RNA interference (RNAi), te whakangao ira ira, me te whakarereketanga o nga huarahi metabolic e uru ana ki te porphyria me nga mate ira e pa ana.
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Pegcetacoplan
Ko te Pegcetacoplan he pegylated cyclic peptide e mahi ana hei aukati awhina C3 kua whakaritea, i whakawhanakehia mo te maimoatanga o nga mate whakauru-whakawhitiwhiti penei i te paroxysmal nocturnal hemoglobinuria (PNH) me te atrophy matawhenua (GA) i roto i te paheketanga macular e pa ana ki te tau.
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Plozasiran
Ko te Plozasiran API he RNA pokanoa iti (siRNA) i hangaia mo te maimoatanga o te hypertriglyceridemia me nga mate o te ngakau me te metabolic. E whai ana i teAPOC3ira, e whakawaehere ana i te apolipoprotein C-III, he kaiwhakahaere matua o te paopaotanga triglyceride. I roto i te rangahau, ka whakamahia a Plozasiran ki te ako i nga rautaki whakaheke lipid-a-RNAi, te motuhake-whakamutunga ira, me nga maimoatanga roa mo nga ahuatanga penei i te whanau chylomicronemia syndrome (FCS) me te dyslipidemia whakauru.
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Zilebesiran
Ko te Zilebesiran API he RNA pokanoa iti (siRNA) i whakawhanakehia mo te maimoatanga o te whakaheke toto. E whai ana i teAGTira, e whakawaehere ana i te angiotensinogen—he waahanga matua o te punaha renin-angiotensin-aldosterone (RAAS). I roto i te rangahau, ka whakamahia a Zilebesiran ki te ako i nga huarahi whakangao ira mo te whakahaere i te pehanga toto mo te wa roa, nga hangarau tuku RNAi, me te mahi whanui o te ara RAAS i roto i nga mate ngakau me nga whatukuhu.
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Palopegteriparatide
Ko te Palopegteriparatide he agonist-agonist-a-parathyroid hormone receptor agonist (PTH1R agonist), i hangaia mo te maimoatanga o te hypoparathyroidism tawhito. He tairitenga pegylated o PTH (1-34) i hangaia hei whakarato i te ture konupūmā mau tonu me te horopeta kotahi-wiki.
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GHRP-6
Ko te GHRP-6 (Growth Hormone Releasing Peptide-6) he hexapeptide synthetic e mahi ana hei secretagogue hormone tupu, e whakaihiihi ana i te tukunga taiao o te tinana o te hormone tupu (GH) ma te whakahohe i te GHSR-1a receptor.
Āhuatanga API:
Pure ≥99%
I hangaia ma te whakahiato peptide-waahanga (SPPS)
Ka tukuna mo te R&D me te whakamahi arumoni
Ko te GHRP-6 he peptide rangahau maha mo te tautoko o te tinana, te whakahou i nga uaua, me te whakarereketanga o te hormonal.
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GHRP-2
Ko te GHRP-2 (Growth Hormone Releasing Peptide-2) he hexapeptide waihanga me te kaha o te homoni tipu secretagogue, i hangaia hei whakaongaonga i te tukunga taiao o te hormone tupu (GH) ma te whakahohe i te kaiwhiwhi GHSR-1a i roto i te hypothalamus me te pituitary.
Āhuatanga API:
Pure ≥99%
Kei te waatea mo te R&D me te tuku hokohoko, me nga tuhinga QC katoa
Ko te GHRP-2 he peptide rangahau nui i roto i nga mara o te endocrinology, te rongoa whakaora, me nga maimoatanga e pa ana ki te tau.
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Hexarelin
Ko te Hexarelin he peptide secretagogue peptide (GHS) tipu tipu me te agonist GHSR-1a kaha, i whakawhanakehia hei whakaongaonga i te tukunga o te hormone tupu (GH). No te whanau ghrelin mimetic, a, e ono nga waikawa amino (he hexapeptide), he pai ake te whakapumautanga o te tinana me te kaha ake o te tuku GH ki nga tairitenga o mua penei i te GHRP-6.
Āhuatanga API:
Pure ≥ 99%
I hangaia ma te whakahiato peptide-waahanga totoka (SPPS)
Ko nga paerewa rite ki te GMP, he iti te endotoxin me nga toenga whakarewa
Te tuku hangore: R&D ki te tauine arumoni
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Melanotana II
Āhuatanga API:
Te parakore teitei ≥ 99%
I whakahiatotia ma te whakahiato peptide peptide (SPPS)
He iti te endotoxin, he iti te toenga whakarewa
Wātea i roto i te R&D ki te tauine arumoni -
Melanotana 1
Ko te Melanotan 1 API ka hangaia ma te whakamahi i te hangarau whakahiato peptide synthesis (SPPS) i raro i nga tikanga whakahaere kounga penei i te GMP.
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Te parakore teitei ≥99%
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Te whakahiato peptide-waa totoka (SPPS)
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Nga paerewa hangahanga rite-GMP
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Nga tuhinga katoa: COA, MSDS, raraunga pumau
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Te tuku tauine: R&D ki nga taumata arumoni
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MOTS-C
Ko te MOTS-C API ka hangaia i raro i nga tikanga tino rite ki te GMP ma te whakamahi i te hangarau peptide peptide synthesis (SPPS) totika hei whakarite i tona kounga teitei, te parakore me te tino pumau mo te rangahau me te whakamahinga rongoa.
Āhuatanga Hua:Pure ≥ 99% (kua whakamanahia e HPLC me LC-MS),
He iti te endotoxin me te toenga whakarewa,
I hangaia i runga i te ICH Q7 me nga tikanga GMP-rite,
Ka taea te whakatutuki i te hanga nui-nui, mai i nga roopu R&D taumata-milligramme ki te taumata karamu me te taumata kirokaramu te tuku arumoni. -
Ipamorelin
Ko te Ipamorelin API he mea whakarite e te **Sitide phase peptide synthesis process (SPPS)** teitei-paerewa (SPPS)** me te tino purenga me te whakamatautau kounga, e tika ana mo te whakamahi paipa moata i roto i te rangahau pūtaiao me te whanaketanga me nga kamupene rongoa.
Ko nga ahuatanga hua ko:
Pure ≥99% (whakamātautau HPLC)
Kaore he endotoxin, he iti te toenga whakarewa, he iti te poke o te katote whakarewa
Whakaratohia he huinga katoa o nga tuhinga kounga: COA, purongo ako tuturu, tātari hihinga poke, aha atu.
Ka taea te whakarite i te taumata karamu ~ te tuku taumata kirokaramu