Ko te Sildenafil Citrate Te maimoatanga o te Erectile Dysfunction 171599-83-0
Taipitopito Hua
| Ingoa | Sildenafil Citrate |
| nama CAS | 171599-83-0 |
| tātai rāpoi ngota | C28H38N6O11S |
| Te taumaha ngota | 666.70 |
| Tau EINECS | 200-659-6 |
| Merck | 14,8489 |
| Kiato | 1.445g/cm3 |
| Te ahua rokiroki | 2-8°C |
| Puka | Paura |
| Tae | Mā |
| Te wairewa | DMSO: >20mg/mL |
Nga kupu taurite
Viagra, Sildenafil citrate; 1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazinecitratessalt; 5-[2-Ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo [5,4-e] pyrimidin-7-onecitratessalt; 1-[[3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl) -4-ethoxyphenyl]sulfonyl]-4-methylpiperazine,2-hydroxy-1,2,3-propanetricarboxylate; SildenafilCitrate(100mg); Sildenafilcitrate,>=99%;Sildenafilcitrate,Profesionalsupply; 5-[2-Ethoxy-5-[(4-methyl-piperazin-1-yl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-onecitrate
Pānga Rongoā
Mahi Rongoa
Ko te Sildenafil citrate he kaitautoko 5-phosphodiesterase whiriwhiri e whakanui ana i te waikawa nitric oxide-ti'aturi, cyclic guanosine monophosphate-mediated vasodilation pulmonary na roto i te whakakore i te pakaru o te cyclic guanosine monophosphate. I tua atu i te toronga tika o nga oko toto pulmonary, ka taea hoki te aukati, te huri ranei i te whakarereketanga o nga uaua.
Nga Taonga rongoa me nga tono
Ko te Sildenafil citrate, te ingoa hokohoko Viagre, e mohiotia ana ko Viagra, he cyclic guanosine monophosphate (cGMP) -specific phosphodiesterase type 5 (PDE5) inhibitor e taea te whakarei ake i te hanganga i muri i te whakahaere waha. Ka taea e te Sildenafil citrate te whakarei ake i te painga o te waikura nitric (NO) ma te whakakore i te momo 5 phosphodiesterase e whakaheke ana i te cyclic guanosine monophosphate (cGMP) i roto i te corpus cavernosum. Whakanuia te taumata o te cGMP i roto i te corpus cavernosum, whakangawari i te uaua maeneene i roto i te corpus cavernosum, te whakanui ake i te rere o te toto, te whakaroa i te wa hanga ure me te whakanui ake i te pakari. Mo nga turoro matekore me te mate erectile. Ka tangohia e nga pakeke te 50 mg a-waha ia wa, tae atu ki te 1 wa ia ra, me te whakamahi i te mea e hiahiatia ana mo te 1 haora i mua i te taatai. Ko te nui rawa atu ko te 0.1g ia wa.
I roto i nga akoranga vivo
I roto i nga kuri kua whakahiatohia, ko te Sildenafil citrate te whakanui i te mahi erectile penile i raro i te whakaongaonga o te nerve pelvic ma te ine i te pehanga intracavernous. Ko te Sildenafil citrate i tino huri i te ngoikoretanga o te carbamoylcholine-stimulated me te aukati i te hanganga superoxide i roto i te kiko cavernosal o nga rapeti hypercholesterolemic. I roto i nga kiore Sprague-Dawley, ka whakapai ake a Sildenafil i te mahi erectile i roto i te waa-waahi-whakaaro, me te tino whakaora i te ra 28 i te horopeta o te 20 mg / kg ia ra. I roto i nga kiore Sprague-Dawley, ko te whakahaeretanga o Sildenafil i hua mai i nga uaua maeneene o te kohinga collagen te tiaki me te tiaki i te whakaaturanga CD31 me te eNOS. I roto i nga kiore Sprague-Dawley, ka tino whakaitihia e Sildenafil te tohu apoptotic me te whakanui ake i te phosphorylation o te akt me te eNOS i whakaritea ki te roopu whakahaere.
