Ste-γ-Glu-AEEA-AEEA-OSU

Ste-γ-Glu-AEEA-AEEA-OSU

Ko te Ste-γ-Glu-AEEA-AEEA-OSU he ngota ngota whakahiato lipid kua hangaia mo te tuku raau taero me te whakakotahi i nga raau taero antibody (ADC). Kei roto i te stearoyl (Ste) hydrophobic hiku, he γ-glutamyl motif arotahi, AEEA mokowhiti mo te ngawari, me te roopu OSu (NHS ester) mo te whakakotahi pai.

 
Rangahau me nga tono:

Ka whakamahia i roto i te whakahiato prodrug me te hoahoa nanocarrier

Ka whakarei ake i te taunekeneke o te membrane pūtau me te tango i nga raau taero

Ka awhina i te taapiri utu-a-pae ki nga peptides, antibodies, kawe kawe ranei

Nga waahanga hua (Gentolex Group):

Te maatanga teitei, te rite-ki-te-kotahi te ester NHS

He pai mo te bioconjugation me te rangahau tuku kua whakaritea

He pai te Ste-γ-Glu-AEEA-AEEA-OSU mo te whanaketanga o te punaha tuku rongoa.