Ko te Leuprorelin Acetate te whakahaere i te hunanga o nga homoni Gonadal
Taipitopito Hua
| Ingoa | Leuprorelin |
| nama CAS | 53714-56-0 |
| tātai rāpoi ngota | C59H84N16O12 |
| Te taumaha ngota | 1209.4 |
| Tau EINECS | 633-395-9 |
| Te hurihanga motuhake | D25 -31.7° (c = 1 i roto i te 1% waikawa ahetiki) |
| Kiato | 1.44±0.1 g/cm3(Te Matapae) |
| Te ahua rokiroki | -15°C |
| Puka | Tata |
| Te whakarea kawa | (pKa) 9.82±0.15 (Whakaahua) |
| Te wairewa | Wairewa ki te wai i te 1mg/ml |
Nga kupu taurite
LH-RHLEUPROLIDE;LEUPROLIDE;LEUPROLIDE(TANGATA);LEUPRORELIN;[DES-GLY10,D-LEU6,PRO-NHET9]-LUTEINIZINGHORMONE-RELEASINGHORMONEHUMAN;(DES-GLY10,D-LEU6,PRO-NHETRING9); DES-GLY10,D-LEU6,PRO-NHET9)-LUTEINIZINGHORMONE-RELEASINGFACTOR;[DES-GLY10,D-LEU6,PRO-NHET9]-LH-RH(TANGATA)
Pānga Rongoā
Ko te Leuprolide, te goserelin, te triprelin, me te nafarelin he maha nga raau taero e whakamahia nuitia ana i roto i nga mahi haumanu ki te tango ovaries mo te maimoatanga o te mate pukupuku u premenopausal me te mate pukupuku prostate.(e kiia ana ko GnRH-a raau taero), he rite te hanga o nga raau taero GnRH-a ki te GnRH me te whakataetae ki nga kaiwhakawhiwhi GnRH pituitary.Arā, ka heke te gonadotropin e hunahia ana e te pituitary, e arai ana ki te heke nui o te taiaki ira i hunahia e te ovary.
Ko te Leuprolide he homoni tuku-gonadotropin (GnRH) tairitenga, he peptide e 9 nga waikawa amino.Ka taea e tenei hua te aukati i te mahi o te punaha pituitary-gonadal, ko te aukati ki nga enzymes proteolytic me te hononga ki te pituitary GnRH receptor he kaha ake i te GnRH, me te mahi o te whakatairanga i te tuku o te luteinizing hormone (LH) e tata ana ki te 20 nga wa. o GnRH.He kaha ake ano te aukati ki te mahi pituitary-gonad i te GnRH.I te waahi tuatahi o te maimoatanga, ka piki ake te homoni whakaihiihi follicle (FSH), LH, estrogen, androgen ranei mo te wa poto, a, na te heke o te urupare o te pituitary gland, ka aukati te hunanga o te FSH, LH me te estrogen, androgen ranei, ka hua i te whakawhirinaki ki nga homoni sex.Ko nga mate taangata (pēnei i te mate pukupuku prostate, endometriosis, me etahi atu) ka whai hua whakaora.
I tenei wa, ko te tote acetate o te leuprolide te nuinga o te whakamahi i te haumanu, no te mea he pai ake te mahi a te leuprolide acetate i te pāmahana rūma.Me whakakore te wai.Ka taea te whakamahi mo te rongoa rongoa mo te endometriosis me te fibroids uterine, te tino pakeketanga o mua, te mate pukupuku o te u premenopausal me te mate pukupuku prostate, me te mahi hoki mo te whakaheke toto uterine e aukati ana, e kore e whai hua mo te rongoa taiaki tikanga.Ka taea hoki te whakamahi hei rongoa i mua i te tangohanga endometrial, ka taea te whakakikorua i te endometrium, te whakaiti i te edema, me te whakaiti i te uaua o te pokanga.
