Semaglutide mo te mate huka momo 2

Ko te Semaglutide he reanga hou o te GLP-1 (glucagon-like peptide-1) analogs, a ko te semaglutide he momo inenga roa kua whakawhanakehia i runga i te hanganga taketake o te liraglutide, he pai ake te painga ki te maimoatanga o te mate huka momo 2.Kua oti i a Novo Nordisk nga rangahau 6 Phase IIIa mo te werohanga semaglutide, a ka tukuna he tono rehitatanga tarukino hou mo te werohanga wiki semaglutide ki te US Food and Drug Administration (FDA) i te Hakihea 5, 2016. I tukuna ano he Tono Whakaaetanga Tauhokohoko (MAA) ki te te European Medicines Agency (EMA).

Ka whakatauritea ki te liraglutide, he roa ake te mekameka aliphatic a semaglutide me te whakanui ake i te hydrophobicity, engari ka whakarereketia te semaglutide me te mekameka poto o te PEG, a ka tino whakanuia tona hydrophilicity.I muri i te whakarereketanga o te PEG, kaore e taea e ia anake te herea ki te albumin, ka hipoki i te waahi hydrolysis enzymatic o DPP-4, engari ka whakaiti ano i te tangohanga renal, te roa o te haurua o te koiora, me te whakatutuki i te painga o te tohanga roa.