Linaclotide mo nga mate pukupuku 851199-59-2
Taipitopito Hua
| Ingoa | Linaclotide |
| nama CAS | 851199-59-2 |
| tātai rāpoi ngota | C59H79N15O21S6 |
| Te taumaha ngota | 1526.74 |
Nga kupu taurite
Linaclotide;Linaclotide;LinaelotideAcetate;Linaelotide;CY-14;Liclotide;Argpessin;L-Tyrosine,L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl- L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-,cyclic(1→6),(2→10),(5→13)-tris(disulfide)
Whakaahuatanga
Ko Linaclotide, he hanganga peptide waihanga kei roto 14 waikawa amino, e pa ana ki te whanau peptide guanosine endogenous, a ko ia anake nga raau taero agonist GC-C (guanylate) Cyclase-C) kua whakaaetia e te FDA mo te maimoatanga o te mate irritable bowel syndrome me te paura (IBS- C) me te mate idiopathic constipation (CIC) i roto i nga pakeke.
Nga Ahuatanga matū
Ko te Linaclotide he paura amorphous ma ki te ma-kore;paku wairewa ki te wai me te wairewa konutai pūhaumāota wai (0.9%).
Pehea te mahi
Ko Linaclotide he guanylate cyclase-C receptor agonist (GCCA) me te analgesic visceral me te mahi endocrine.Ka taea e te linaclotide me tana metabolite kaha te here ki te kaiawhina guanylate cyclase-C (GC-C) i runga i te mata maramara o te epithelium intestinal iti.I roto i nga tauira kararehe, ka whakaitihia e te linaclotide te mamae o te visceral me te whakanui ake i te whakawhitinga gastrointestinal na roto i te whakahohenga o te GC-C, a, i roto i te tangata, ka whakanui ano te tarukino i te whakawhitinga koroni.Ko te hua o te whakahohenga GC-C ka piki ake te whakaurunga intracellular me te extracellular cGMP (cyclic guanosine monophosphate).Ka taea e te cGMP extracellular te whakaheke i te ngohe o nga muka nerve mamae me te whakaiti i te mamae o roto o nga kararehe tauira.Ka taea e Intracellular cGMP te whakanui ake i te whakamaarama o te chloride me te bicarbonate i roto i te whekau iti ma te whakahohe i te CFTR (cystic fibrosis transmembrane conductance regulator), i te mutunga ka arahi ki te pikinga o te rerenga o te wai intestinal iti me te tere o te whakawhiti whekau iti.
FAQ
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