Terlipressin Acetate mo te Esophageal Variceal toto
Taipitopito Hua
| Ingoa | N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin |
| nama CAS | 14636-12-5 |
| tātai rāpoi ngota | C52H74N16O15S2 |
| Te taumaha ngota | 1227.37 |
| Tau EINECS | 238-680-8 |
| Kohuatanga | 1824.0±65.0 °C (Te Matapae) |
| Kiato | 1.46±0.1 g/cm3(Te Matapae) |
| Nga tikanga rokiroki | Puritia ki te waahi pouri, te hau koretake, Rokiroki ki roto i te pouaka tio, i raro i te -15°C. |
| Te whakarea kawa | (pKa) 9.90±0.15 (Te Matapae) |
Nga kupu taurite
[N-α-Triglycyl-8-lysine]-vasopressin;130:PN: WO2010033207SEQID:171claiMedprotein; 1-Triglycyl-8-lysineVasopressin; Nα-Glycyl-glycyl-glycyl-[8-lysine]-vasopressin; Nα-Glycyl-glycyl-glycyl-lysine-vasopressin; Nα-Glycylglycylglycyl-vasopressin; Nα-Gly-Gly-Gly-8-Lys-vasopressin; Terlipressin, Terlipressine, Terlipressina, Terlipressinum.
Whakaahuatanga
Ko te Terlipressin, ko tona ingoa matū ko te triglycyllysine vasopressin, he waihanga hou mo te whakarite vasopressin mahi roa. He momo prodrug, he hohekore noa iho. Ka mahia e te aminopeptidase in vivo ki te "tuku" i te vasopressin lysine kaha i muri i te tango i nga toenga glycyl e toru i tona pito-N. Na reira, ko te terlipressin te mahi hei puna e tuku ana i te lysine vasopressin i te tere tere.
Ko te hua rongoa o te terlipressin ko te kirimana i nga uaua maeneene vascular splanchnic me te whakaheke i te rere o te toto splanchnic (pēnei i te whakaheke toto i roto i te mesentery, spleen, kōpū, me etahi atu), na reira ka whakaiti i te rere toto tomokanga me te pehanga kuaha. I tetahi atu ringa, ka taea hoki te whakaheke i te plasma Ko te painga o te renin concentration, na reira ka piki ake te rere o te toto renal, te whakapai ake i te mahi renal me te whakanui ake i te whakaputa urine i roto i nga turoro me te mate pukupuku hepatorenal. Ko Terlipressin i tenei wa ko te rongoa anake ka taea te whakapai ake i te tere o te oranga o nga turoro me te whakaheke toto o te esophageal variceal. I whakamahia te nuinga i roto i te maimoatanga haumanu o te whakaheke toto variceal. I tua atu, kua pai te whakamahi i te terlipressin ki te ate me te whatukuhu. I te nuinga o te waa, tera pea ka whai waahi pai ki te noho tahi i te wiri kino me te whakaora ngakau. Ka whakatauritea ki te vasopressin, he roa te paanga, kaore e puta he raruraru kino, tae atu ki te fibrinolysis me nga raruraru nui i roto i te punaha cardiovascular, a he mea ngawari ki te whakamahi (i roto i te werohanga), he pai ake mo te tiaki tino nui. Te whakaoranga me te maimoatanga o nga turoro mate kino.
