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Ingoa | Chondroitin pūkawa |
nama CAS | 9007-28-7 |
tātai rāpoi ngota | C13H21NO15S |
Te taumaha ngota | 463.36854 |
Tau EINECS | 232-696-9 |
Te wairewa | Wairewa ki te wai |
Maamaa | 98% |
Rokiroki | Rokiroki i te pāmahana auau |
Puka | Paura |
Tae | He ma ki waho-ma |
Te takai | Peeke PE + Peeke Aluminium |
poly-1(2/3)-n-acetyl-2-amino-2-deoxy-3-o-beta-d-glucopyranurosyl-4-(6)sulfonyl-d-galactose;chondroitinpoly pūkawa;chondroitin sulfates;chondroiti nsulfuricacid;waikawa pungatara chondroitin;chhonsurid;CSO;(5ξ)-2-(Carboxyamino)-2-deoxy-3-O-β-D-glucopyranuronosyl-4-O-sulfo-α-L-arabino-hexopyranose
Whakaahuatanga
Ko te Chondroitinsulfate (CS) he mucopolysaccharide waikawa i tangohia me te purea mai i te kiko cartilage kararehe.He rereke nga hanganga o te Chondroitin sulfate penei i te A, C, D, E, H me K. Ko te chondroitin sulfate i roto i te taiao ka kitea te nuinga i roto i te cartilage kararehe, wheua korokoro, wheua nasal (41% i roto i te poaka), bovine, horse septum me te trachea (kei roto 36% ki te 39%), kei roto ano etahi atu kopa penei i nga koiwi waewae, nga hononga, te kiri, te kiore, me etahi atu.He tino whai rawa te kiko o te kirikiri ika, penei i te 50% ki te 60% i roto i te kiwi mango, me te iti rawa o te kiko hono.
Mo te mate atherosclerotic coronary, ka piki ake te toto toto me te cholesterol, arteriosclerosis, angina pectoris, myocardial ischemia, myocardial infarction, me etahi atu i roto i nga turoro me te mate ngakau coronary.
Mahi Rongoa
He rite nga paanga o te Rapamycin (RAPA) ki te FK506.I roto i te maha o nga whakamatautau haumanu, ko ona paanga taha i kitea he inenga-whakaaro me te whakahuri, me te RAPA i nga pota rongoa kaore i kitea he nui te nephrotoxicity me te kore he hyperplasia gingival.Ko te tino paitini me nga paanga taha ko: te mahunga, te nausea, te whanoke, te ihu, me te mamae tahi.Ko nga mate kino o te taiwhanga ko: thrombocytopenia, leukopenia, hemoglobin iti, hypertriglyceridemia, hypercholesterolemia, hyperglycemia, whakaneke ake i nga enzyme ate (SGOT, SGPT), lactate dehydrogenase teitei, hypokalemia, Hypomagnesemia, me etahi atu. Ko nga taumata phosphate plasma e kiia ana he roa te whakaputanga o te phosphate mai i te whatukuhu kua whakatokia e te RAPA-based immunosuppressive therapy.Pērā i ētahi atu immunosuppressants, he nui ake te tupono o te mate o te RAPA, me te kii he nui ake te kaha o te mate pneumonia, engari ko te puta o etahi atu mate tupono kaore e tino rerekee i te CsA.
Painga Toxicological
Ko te chondroitin sulfate kei roto i te kiko kirikiri tangata me te kararehe.Ko te whakaritenga rongoa kei roto i te nuinga o nga waahanga e rua o te chondroitin sulfate A me te chondroitin sulfate C.Ko ona hua rongoa ko enei e whai ake nei: ka taea e te chondroitin sulfate te tango i nga lipids me nga lipoproteins i roto i te toto, te tango i te cholesterol mai i nga oko toto huri noa i te ngakau, te aukati me te rongoa i te atherosclerosis, me te whakanui ake i te tere hurihanga o nga lipids me nga waikawa ngako i roto i nga pūtau.Ka taea e te Chondroitin sulfate te aukati me te rongoa i nga mate ngakau coronary.He hua anti-atherosclerosis me te hanga tohu anti-atherogenic i runga i nga tauira arteriosclerosis whakamatautau;ka whakanui ake i nga peka korokoro, te tohanga whakaraerae ranei o te atherosclerosis, a ka taea te whakatere i te whakamatautau toto coronary arteriosclerosis, embolism ranei.Te whakaora, te whakahou me te whakatikatika i te necrosis myocardial, te whakaheke ranei.Ka taea e ia te whakanui ake i te koiora o te waikawa ribonucleic messenger pūtau (mRNA) me te waikawa deoxyribonucleic (DNA) me te whai hua ki te whakatairanga i te whakawhitinga pūtau.He iti te mahi anticoagulant.Ko te chondroitin sulfate he paanga anticoagulant ahua, a ko ia 1 mg o te chondroitin sulfate A he rite ki te mahi anticoagulant o 0.45U o te heparin.Ko tenei mahi anticoagulant kaore i te whakawhirinaki ki te antithrombin III ki te mahi i tana mahi, ka taea e ia te mahi anticoagulant na roto i te punaha fibrinogen.Ko te Chondroitin sulfate ano he anti-inflammatory, he tere te whakaora i nga patunga me nga paanga anti-puku.