Carbetocin hei Aukati i te Paheketanga Uterine me te Paheketanga o te Whanau
Taipitopito Hua
| Ingoa | CARBETOSIN |
| nama CAS | 37025-55-1 |
| tātai rāpoi ngota | C45H69N11O12S |
| Te taumaha ngota | 988.17 |
| Tau EINECS | 253-312-6 |
| Te hurihanga motuhake | D -69.0° (c = 0.25 i roto i te 1M waikawa ahetiki) |
| Kohuatanga | 1477.9±65.0 °C (Te Matapae) |
| Kiato | 1.218±0.06 g/cm3(Te Matapae) |
| Nga tikanga rokiroki | -15°C |
| Puka | paura |
Nga kupu taurite
BUTYRYL-TYR(ME)-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2, (SULFIDEBONDBETWEENBUTYRYL-4-YLANDCYS); BUTYRYL-TYR(ME)-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2TRIFLUOROACETATESALT; (BUTYRYL1, TYR(ME)2)-1-CARBAOXYTOC INTRIFLUOROACETATESALT; (BUTYRYL1, TYR(ME)2)-OXYTOCIN; (BUTYRYL1,TYR(ME)2)-OXYTOCINTRIFLUOROACETATESALT; CARBETOCIN; CARBETOCINTRIFLUOROACETATESALT; (2-O-METHYLTYROSINE)-DE-AMINO-1-CARBAOXYTOCIN
Mahi koiora
Ko Carbetocin, he tairitenga oxytocin (OT), he agonist kaiwhakawhiwhi oxytocin me te Ki o 7.1 nM. Ko te Carbetocin he hononga teitei (Ki=1.17 μM) mo te chimeric N-terminus o te kaikawe oxytocin. Ka taea e Carbetocin te rangahau whakaheke toto i muri i te whanautanga. Ka taea e Carbetocin te kuhu ki roto i te arai toto-roro me te mahi antidepressant-rite ma te whakahohe i nga kaiwhakawhiwhi oxytocin i roto i te CNS.
Mahi
Ko te Carbetocin he oxytocin 8-peptide tairitenga hanga roa me nga ahuatanga agonist, a he rite ona taonga haumanu me te rongoa ki era o te oxytocin puta noa. Pērā i te oxytocin, ka herea te carbetocin ki nga kaiwhakawhiwhi o te homoni o te uaua maeneene o te uterine, ka paheke te manawa o te kōpū, te whakanui ake i te auau me te whakanui ake i te tangi o te uterine i runga i nga whakawhitinga o te taketake. Ko nga taumata o te kaikawe oxytocin i roto i te kōpū he iti i roto i te ahua kaore i te hapu, ka piki ake i te wa e hapu ana, me te tihi i te wa e hapu ana. No reira, karekau he painga o te carbetocin ki te kopu kore e hapu ana, engari he kaha te kaha o te whakangao i te uterine uterine ki runga i te kōpū hapu me te kōpū whanau hou.
Huri Mana
Ka whakahaerehia nga huringa i runga i te tikanga. I runga i te paanga me te tupono me te taumahatanga, ka whakarōpūhia nga huringa hei Meiha, Iti me te Pae. Ko nga huringa o te waahi he iti te paanga ki te haumaru me te kounga o te hua, na reira kaore e hiahiatia he whakaaetanga me te panui ki te kaihoko; Ko nga huringa iti e pa ana ki te haumaru me te kounga o te hua, me whakamohio atu ki te kaihoko; Ko nga huringa nui he nui ake te paanga ki te haumaru me te kounga o te hua, me whakaae mai te kaihoko.
E ai ki te tikanga, ka timatahia te mana whakarereke me te tono huringa e whakaahuahia ai nga korero whakarereke me te whaitake mo te huringa. Ka mahihia te arotake i muri i te tono, ka mahia ma te whakarereke i nga tari e pa ana. I tenei wa, ka whakarōpūhia te mana huringa ki te taumata Meiha, taumata Whanui me te taumata Iti. Whai muri i te arotakenga tika me te whakarōpūtanga, me whakamana nga mana huringa taumata katoa e te Kaiwhakahaere QA. Ka mahia te mana huringa i muri i te whakaaetanga e ai ki te mahere mahi. Ka kati te mana huringa i muri i te whakau a QA kua tika te whakatinanatanga o te mana huringa. Mēnā he whakamohiotanga a te kiritaki, me whakamohiohia te kiritaki i te wa tika i muri i te whakaaetanga o te mana huringa
