Carbetocin to Prevent Uterine Contraction and Postpartum Hemorrhage Featured Image

Carbetocin hei Aukati i te Paheketanga Uterine me te Paheketanga o te Whanau

Whakaahuatanga Poto:

Ingoa: CARBETOCIN

Nama CAS: 37025-55-1

tātai rāpoi: C45H69N11O12S

Te taumaha ngota: 988.17

Tau EINECS: 253-312-6

Te hurihanga motuhake: D -69.0° (c = 0.25 i roto i te 1M waikawa ahetiki)

Wāhi koropupū: 1477.9±65.0 °C (Te Matapae)

Kiato: 1.218±0.06 g/cm3(Whakaahua)

Nga tikanga rokiroki: -15°C

Puka: paura

Tukuna he imeera ki a matou

Taipitopito Hua

Tohu Hua

Taipitopito Hua

Ingoa	CARBETOSIN
nama CAS	37025-55-1
tātai rāpoi ngota	C45H69N11O12S
Te taumaha ngota	988.17
Tau EINECS	253-312-6
Te hurihanga motuhake	D -69.0° (c = 0.25 i roto i te 1M waikawa ahetiki)
Kohuatanga	1477.9±65.0 °C (Te Matapae)
Kiato	1.218±0.06 g/cm3(Te Matapae)
Nga tikanga rokiroki	-15°C
Puka	paura

Nga kupu taurite

BUTYRYL-TYR(ME)-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2, (SULFIDEBONDBETWEENBUTYRYL-4-YLANDCYS);BUTYRYL-TYR(ME)-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2TRIFLUOROACETATESALT;(BUTYRYL1, TYR(ME)2)-1-CARBAOXYTOC INTRIFLUOROACETATESALT;(BUTYRYL1, TYR(ME)2)-OXYTOCIN;(BUTYRYL1,TYR(ME)2)-OXYTOCINTRIFLUOROACETATESALT;CARBETOCIN;CARBETOCINTRIFLUOROACETATESALT;(2-O-METHYLTYROSINE)-DE-AMINO-1-CARBAOXYTOCIN

Mahi koiora

Carbetocin, he tairitenga oxytocin (OT), he agonist whakawhiwhi oxytocin me te Ki o 7.1 nM.He hononga teitei a Carbetocin (Ki=1.17 μM) mo te chimeric N-terminus o te kaikawe oxytocin.Ka taea e Carbetocin te rangahau whakaheke toto i muri i te whanautanga.Ka taea e Carbetocin te kuhu ki roto i te arai toto-roro me te mahi antidepressant-rite ma te whakahohe i nga kaiwhakawhiwhi oxytocin i roto i te CNS.

Mahi

Ko te Carbetocin he oxytocin 8-peptide tairitenga hanga roa me nga ahuatanga agonist, a he rite ona taonga haumanu me te rongoa ki era o te oxytocin puta noa.Ka rite ki te oxytocin, ka herea te carbetocin ki nga kaiwhakawhiwhi o te homoni o te uaua maeneene o te kopu, na te mea ka paheke te manawa o te kōpū, te whakanui ake i te auau me te whakanui ake i te tangi o te uterine i runga i nga whakawhitinga o te taketake.Ko nga taumata o te kaikawe oxytocin i roto i te kōpū he iti i roto i te ahua kaore i te hapu, ka piki ake i te wa e hapu ana, me te tihi i te wa e hapu ana.No reira, karekau he painga o te carbetocin ki te kopu kore e hapu ana, engari he kaha te kaha o te whakangao o te uterine ki runga i te kōpū hapu me te kōpū hou kua puta.

Huri Mana

Ka whakahaerehia nga huringa i runga i te tikanga.I runga i te paanga me te tupono me te taumahatanga, ka whakarōpūhia nga huringa hei Meiha, Iti me te Pae.Ko nga huringa o te waahi he iti te paanga ki te haumaru me te kounga o te hua, na reira kaore e hiahiatia he whakaaetanga me te panui ki te kaihoko;Ko nga huringa iti ka pa ki te haumaru me te kounga o te hua, me whakamohio atu ki te kaihoko;Ko nga huringa nui he nui ake te pa ki te haumaru me te kounga o te hua, me whakaae mai te kaihoko.

E ai ki te tikanga, ka timatahia te mana whakarereke me te tono huringa e whakaahuahia ai nga taipitopito whakarereke me te whaitake mo te huringa.Ka mahia te arotake i muri i te tono, ka mahia ma te whakarereke i nga tari e pa ana.I tenei wa, ka whakarōpūhia te mana huringa ki te taumata Meiha, taumata Whanui me te taumata Iti.Whai muri i te aro mātai tika me te whakarōpūtanga, me whakamana nga mana huringa taumata katoa e te Kaiwhakahaere QA.Ko te mana huringa ka mahia i muri i te whakaaetanga e ai ki te mahere mahi.Ka kati te mana huringa i muri i te whakau a QA kua tika te whakatinanatanga o te mana huringa.Mēnā e pā ana ki te whakamohiotanga o te kiritaki, me whakamohiotia te kiritaki i te wa tika i muri i te whakaaetanga o te mana huringa

Tōmua: Ko te Atosiban Acetate e whakamahia ana mo te whanautanga o mua

Panuku: Cetrorelix Acetate hei aukati i te whanautanga o mua 120287-85-6

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